abstract：:We characterized vascular reactivity to endothelin-1 (ET-1) in mesenteric vessels from DOCA-salt hypertensive and SHAM control mice and assessed the effect that endothelial-derived vasodilators have on ET-1-induced vasoconstriction. Changes in the diameter of unpressurized small mesenteric arteries and veins (100- to ...

journal_title：Vascular pharmacology

authors： Pérez-Rivera AA,Fink GD,Galligan JJ

更新日期：2005-06-01 00:00:00

abstract：:We have studied the therapeutic efficacy of the sodium alginate in experimental immune complex glomerulonephritis. Bovine serum albumin (BSA) nephritis was induced in rats by a subcutaneous immunization and daily intravenous administration of BSA. Sodium alginate at two different doses (25 and 50 mg/kg) was administer...

journal_title：Vascular pharmacology

authors： Mirshafiey A,Borzooy Z,Abhari RS,Razavi A,Tavangar M,Rehm BH

更新日期：2005-06-01 00:00:00

abstract：:The present study was undertaken to investigate endothelial function and epoxyeicosatrienoic acids (EETs), which is a cytochrome P-450 monooxygenase (CYP) metabolite and one of the candidates as an endothelium-derived hyperpolarizing factor (EDHF) in the renal artery isolated from short-term hypercholesterolemic rabbi...

journal_title：Vascular pharmacology

authors： Taniguchi J,Honda H,Shibusawa Y,Iwata T,Notoya Y

更新日期：2005-06-01 00:00:00

abstract：:The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic-reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of contractile function. Additionally, the A3AR may attenuate vascular dysfunction and improve long-term outcome from myocardial in...

journal_title：Vascular pharmacology

authors： Headrick JP,Peart J

更新日期：2005-04-01 00:00:00

abstract：:There is evidence that dihydropyridine calcium antagonists (DHP) play a beneficial role during the development of atherosclerosis. Since antioxidative properties of this substance class may be important, we investigated the antioxidative potency of the DHP prototype calcium channel antagonist nifedipine, the long acti...

journal_title：Vascular pharmacology

authors： Berkels R,Breitenbach T,Bartels H,Taubert D,Rosenkranz A,Klaus W,Roesen R

更新日期：2005-03-01 00:00:00

abstract：:Impaired endothelial function is recognised as one of the earliest events of atherogenesis. Endothelium-dependent vasomotion has been the principal method to assess endothelial function. In this article, we will discuss the clinical value of the different techniques to evaluate endothelium-dependent vasomotion. To dat...

journal_title：Vascular pharmacology

authors： Asselbergs FW,van der Harst P,Jessurun GA,Tio RA,van Gilst WH

更新日期：2005-02-01 00:00:00

abstract：:Cigarette smoking is implicated as a major risk factor in the development of cardiovascular and cerebrovascular diseases. Creatine kinase (CK) and its isoforms (CK-MM, MB, BB) have been advocated as sensitive markers in the assessment of cardiac and cerebral damage. Therefore, in the present study, we report the isoen...

journal_title：Vascular pharmacology

authors： Anbarasi K,Vani G,Balakrishna K,Devi CS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Immunosuppressive agents are at the forefront of preventing organ rejection after transplantation. However, their effects on vascular smooth muscle cell-mediated intimal hyperplasia that occurs in post-transplant coronary artery disease are less well known. METHODS AND RESULTS:We investigated the in vitro e...

journal_title：Vascular pharmacology

authors： Hafizi S,Mordi VN,Andersson KM,Chester AH,Yacoub MH

更新日期：2004-05-01 00:00:00

abstract：:The antiplatelet and antithrombotic activities of a newly synthesized CP201, 2-(3,5-di-tert-butyl-4-hydroxyl)-3-chloro-1,4-naphthoquinone on human platelet aggregation in vitro and murine pulmonary thrombosis in vivo were examined. In addition, the antiplatelet activity of CP201 involved in calcium-signaling cascade w...

journal_title：Vascular pharmacology

authors： Jin YR,Hwang KA,Cho MR,Kim SY,Kim JH,Ryu CK,Son DJ,Park YH,Yun YP

更新日期：2004-02-01 00:00:00

abstract：:We investigated the regulation of the epithelial sodium channel (ENaC) in human bone marrow endothelial cells (HBMEC) responding to mineralocorticoid hormones and other accessory effectors. The message for both the mineralocorticoid receptor (MCR) and the alpha subunit of ENaC was expressed in HBMEC as predicted bands...

journal_title：Vascular pharmacology

authors： Chen W,Valamanesh F,Mirshahi T,Soria J,Tang R,Agarwal MK,Mirshahi M

更新日期：2004-01-01 00:00:00

abstract：:Sixty-seven male patients with hypercholesterolemia, divided into three groups according to apolipoprotein E phenotype (33 with apoE3/ 3 phenotype, E3 group; 23 with 2/2 or 2/3, E2+ group; 11 with 4/4 or 4/3, E4+ group), received daily 20-40 mg of fluvastatin for 12 weeks. The levels of triglyceride (TG), cholesterol ...

journal_title：Vascular pharmacology

authors： Dergunov AD,Perova NV,Visvikis S,Siest G

更新日期：2003-12-01 00:00:00

abstract：:Tyrosine kinase pathway has been shown to be involved in the effects of hypoxia in pulmonary arteries, but its role in pulmonary vein is not known. The aims of this study were to determine the effect of hypoxia in sheep isolated pulmonary veins and to identify the role of tyrosine kinase pathway in hypoxic response. G...

journal_title：Vascular pharmacology

authors： Uzun O,Tuncay Demiryürek A

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to investigate the effect of acute hypercapnia due to the mechanical hypoventilation on the oxidative metabolism of peripheral blood neutrophils in the rabbit. METHODS:The study was performed on 24 Chinchilla rabbits, randomized into normo- and hypercapnia groups (P(a)CO(2)...

journal_title：Vascular pharmacology

authors： Billert H,Drobnik L,Podstawska D,Włodarczyk M,Kurpisz M

更新日期：2003-02-01 00:00:00

abstract：:tert-Butyl hydroperoxide (t-BOOH), a membrane permeant oxidant, elicits enhanced vasoconstriction of perfused kidney and mesenteric arterial beds isolated from DOCA-salt-induced hypertensive rats. We hypothesize that enhanced vasoconstriction to t-BOOH during DOCA-salt hypertension involves free radical species and de...

journal_title：Vascular pharmacology

authors： Awe SO,Tsakadze NL,D'Souza SE,Adeagbo AS

更新日期：2003-01-01 00:00:00

abstract：:This study was designed to study the influence of Sacoglottis gabonensis stem bark extract on the metabolic and cytotoxic side effects of 2,4-dinitrophenyl hydrazine (2,4-DNPH) on the brain and blood using male weaving rats as the experimental model. This was after the effect of the bark extract and bergenin, its isol...

journal_title：Vascular pharmacology

authors： Maduka HC,Okoye ZS,Eje A

更新日期：2002-12-01 00:00:00

abstract：:Phosphorylation of proteins on tyrosine acts as a reversible and specific trigger mechanism, forming or disrupting regulatory connections between proteins. Tyrosine kinases and phosphatases participate in multiple cellular processes, and considerable evidence now supports a role for tyrosine phosphorylation in vascula...

journal_title：Vascular pharmacology

authors： Bogatcheva NV,Garcia JG,Verin AD

更新日期：2002-11-01 00:00:00

abstract：:Elevated plasma levels of factor VII and fibrinogen are risk factors for cardiovascular disease, especially arterial thrombosis. Oral contraceptive use increases factor VII and fibrinogen plasma levels. It has been described that DNA polymorphisms are associated with the plasma levels of hemostatic variables and their...

journal_title：Vascular pharmacology

authors： Bloemenkamp KW,de Maat MP,Dersjant-Roorda MC,Helmerhorst FM,Kluft C

更新日期：2002-08-01 00:00:00

abstract：:We have previously reported that prolonged exposure of porcine coronary arteries to adenosine agonists upregulates protein kinase C (PKC) through the activation of adenosine A1 receptor-coupled to pertussis toxin sensitive G-protein(s) [Am. J. Physiol. 264 (1993) H1465; Am. J. Physiol. 269 (1995) H1619]. The mechanism...

journal_title：Vascular pharmacology

authors： Nayeem MA,Mustafa SJ

更新日期：2002-07-01 00:00:00

abstract：:Successful drug delivery to the central nervous system (CNS) is highly dependent on DMPK as well as physicochemical properties and it is therefore important to characterise these properties and take them into account when designing chemical lead series that act at CNS targets. Since the drug discovery/development proc...

journal_title：Vascular pharmacology

authors： Lundquist S,Renftel M

更新日期：2002-06-01 00:00:00

abstract：:The endothelium synthesizes and releases nitric oxide (NO) to maintain homeostatic function. Under basal conditions, endothelium-derived NO maintains a nonthrombogenic surface, prohibits leukocyte attachment, and promotes vascular relaxation. In the setting of clinical syndromes associated with the development of athe...

journal_title：Vascular pharmacology

authors： Russo G,Leopold JA,Loscalzo J

更新日期：2002-05-01 00:00:00

abstract：:Macrophages are important participants in the development of atherosclerotic lesions, in cholesterol accumulation, as mediators of the immune response, and as sources of secreted enzymes and growth factors. Besides potentially contributing to local oxidation of lesion lipoproteins, many aspects of macrophage function ...

journal_title：Vascular pharmacology

authors： Jessup W,Wilson P,Gaus K,Kritharides L

更新日期：2002-04-01 00:00:00

abstract：:Recent studies evidence that peroxynitrite is spontaneously formed when nitric oxide (NO) and superoxide coexist and suggest that it is likely to be involved in the destruction of the pancreatic beta cells. We examined whether drugs that inhibit nitric oxide synthase (NOS) or scavenge peroxynitrite could abrogate STZ-...

journal_title：Vascular pharmacology

authors： Rao VS,Santos FA,Silva RM,Teixiera MG

更新日期：2002-03-01 00:00:00

abstract：:Potassium channel dysfunction plays a role in the pathogenesis of a number of vascular diseases including pulmonary and systemic hypertension, diabetes, and complications of atherosclerosis. Two types of K+ channels that are known to be prevalent and contribute significantly to the repolarization of vascular smooth mu...

journal_title：Vascular pharmacology

authors： Korovkina VP,England SK

更新日期：2002-01-01 00:00:00